AskDefine | Define cytotoxicity

Dictionary Definition

cytotoxicity n : the degree to which something is toxic to living cells

User Contributed Dictionary



  1. the state of being toxic to cells

Related terms

Extensive Definition

Cytotoxicity is the quality of being toxic to cells. Examples of toxic agents are a chemical substance or an immune cell.
Cytotoxicity can be measured by the MTT assay, Trypan blue (TB) assay, Sulforhodamine B (SRB) assay, WST assay and clonogenic assay.
Antibody-dependent cell-mediated cytotoxicity (ADCC) describes the cell-killing ability of certain lymphocytes, which requires the target cell being marked by an antibody. Lymphocyte-mediated cytotoxicity, on the other hand, does not have to be mediated by antibodies; nor does complement-dependent cytotoxicity (CDC), which is mediated by the complement system.
Three groups of cytotoxic lymphocytes are distinguished:

External links

cytotoxicity in German: Zytotoxizität
cytotoxicity in Spanish: Citotoxicidad
cytotoxicity in French: Cytotoxicité
cytotoxicity in Norwegian: Cellegift
cytotoxicity in Russian: Противоопухолевые препараты, цитостатические препараты
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